陈沁，博士，教授，博士生导师，上海市植物生理学会副理事长，1999年博士毕业于南京农业大学，2011年10月起任最安全的网上投注平台副经理。曾获上海市育才奖、宝钢优秀教师奖、国家质检总局科技兴检奖、公司三八红旗手、公司青年教师教学竞赛三等奖、公司教学名师等。主持和参与科技部、国家自然科学基金、上海市科委、教委和农委科研项目及横向项目20余项。先后在Food Chemistry，European Journal of Medicinal Chemistry等专业期刊上发表论文100多篇，申请专利10项，授权专利2项；担任NOTULAE BOTANICAE HORTI AGROBOTANICI杂志的编委。

电话： 66134332

邮箱： chenqincc@shu.edu.cn

主要研究领域

主要从事生化与分子生物学相关交叉领域的研究，包括1）过敏原的检测方法及致敏机理研究；2）II型糖尿病治疗药物的发现机理研究；3）动物疫病和食品安全预警方法的研究等。

近五年主要项目 

1. 科技部国家重点研发计划，2016YFD0501101，潜在入侵的畜禽疫病监测与预警技术研究，2016/07-2020/12，138万元。

2. 国家科技支撑计划, 2013BAD12B06, 外来动物疫病与新发动物疫病预警与阻断技术研究与开发,2013/01-2017/12, 230万元。

3. 自然基金青年基金，31201306，热处理调控花生过敏原Ara h 2致敏性的机制研究，2013/01-2015/12，22万元

4．上海市，食品科学团队建设，2013.01-2015.12，37万元。

5. 横向，新型复方季铵盐-醛类消毒剂配伍特性的研究，2016/05-2018/06，10万元。

6. 横向，进口食品风险数据模型和差异化分析数据库的构建, 2017.12.1-2019.4.30,30万元

7. 横向，邻苯二甲醛类复合消毒剂性能优化及中试生产工艺开发, ,2018.4.16-2019.12.31,  25万元

代表性研究成果

1.   花生过敏是世界上最常见的食物过敏之一，具有长期性、普遍性、伴随终生等特点。本研究发现不同热处理的花生制品均会引起小鼠不同程度的过敏且烘烤花生致敏力最强，而模拟胃液消化实验结果也表明烘烤花生的致敏蛋白具有极强的耐消化性，进一步证明烘烤花生致敏性较强；紫外及圆二色谱的光谱数据则从主要花生过敏原蛋白二级、三级结构的改变上证明了经烘烤之后蛋白结构改变较大，导致其致敏性发生了变化。

2.   研制了戊二醛癸甲溴铵复合消毒剂（GD）新型消毒剂配方，并探讨GD对金黄色葡萄球菌（Staphylococcus aureus），白色念珠菌（Candida albicans），马动脉炎病毒和马疱疹病毒的作用机理。在以上实验的基础上，生产了消毒剂的中试产品。杀菌性能、现场试验、腐蚀性和稳定性等试验的结果表明中试产品符合研制的预期，且贮存期可达2年，现场杀菌效果优于采样地所用的消毒剂。

近五年代表性论文

[1] Niu B, Liang C, Lu Y, et al. Glioma stages prediction based on machine learning algorithm combined with protein-protein interaction networks. Genomics 2020; 112(1): 837-847.

[2] Zhou G, Zhao M, Liang R, et al. A Study of the Mechanism of Binding between Neratinib and MAD2L1 Based on Molecular Simulation and Multi-spectroscopy Methods. Current Pharmaceutical Design 2019; 25(40): 4287-4295.

[3] Zhang T, Shi Y, Zhao Y, et al. Different thermal processing effects on peanut allergenicity. Journal Of the Science Of Food And Agriculture 2019; 99(5): 2321-2328.

[4] Yuan D, Kong J, Fang X, Chen Q. A graphene oxide-based paper chip integrated with the hybridization chain reaction for peanut and soybean allergen gene detection. Talanta 2019; 196: 64-70.

[5] Yuan D, Fang X, Liu Y, Kong J, Chen Q. A hybridization chain reaction coupled with gold nanoparticles for allergen gene detection in peanut, soybean and sesame DNAs. Analyst 2019; 144(12): 3886-3891.

[6] Yi J, Zhang Y, Lin W, Niu B, Chen Q. Effect of polyhexamethylene biguanide functionalized silver nanoparticles on the growth of Staphylococcus aureus. Fems Microbiology Letters 2019; 366(4).

[7] Xia S, Chen Q, Niu B. CD28: A new drug target for immune disease. Current drug targets 2019.

[8] Niu B, Lu Y, Wang J, et al. 2D-SAR, Topomer CoMFA and molecular docking studies on avian influenza neuraminidase inhibitors. Computational And Structural Biotechnology Journal 2019; 17: 39-48.

[9] Ma J, Cao C, Shyamal G, et al. Detection of ICOS~+ T cells by multiplex immunohistochemistry in tumor tissue and its clinical significance in hepatocellular carcinoma. China Oncology 2019; 29(5): 352-361.

[10] Lu Y, Wang S, Wang J, et al. An Epidemic Avian Influenza Prediction Model Based on Google Trends. Letters In Organic Chemistry 2019; 16(4): 303-310.

[11] Lu Y, Deng X, Chen J, et al. Risk analysis of African swine fever in Poland based on spatio-temporal pattern and Latin hypercube sampling, 2014-2017. Bmc Veterinary Research 2019; 15.

[12] Liang R, Lu Y, Qu X, et al. Prediction for global African swine fever outbreaks based on a combination of random forest algorithms and meteorological data. Transboundary And Emerging Diseases 2019.

[13] Li Y, Wan Z, Hu Y, et al. A mismatch-tolerant RT-quantitative PCR: application to broad-spectrum detection of respiratory syncytial virus. Biotechniques 2019; 66(5): 225-230.

[14] Jiaqiang, Zheng B, Goswami S, et al. PD1(Hi) CD8(+) T cells correlate with exhausted signature and poor clinical outcome in hepatocellular carcinoma. Journal for Immunotherapy Of Cancer 2019; 7(1).

[15] Hu Y, Zhou G, Zhang C, et al. Identify Compounds' Target Against Alzheimer's Disease Based on In-Silico Approach. Current Alzheimer Research 2019; 16(3): 193-208.

[16] Hu S, Li Y, Zhou Y, et al. Determination of 50 non-edible additives in health food using the QuEChERS method and liquid chromatography-tandem mass spectrometry. Chinese Journal Of Chromatography 2019; 37(7): 701-711.

[17] Chen J, Zhou G, Xie J, et al. Dairy Safety Prediction Based on Machine Learning Combined with Chemicals. Medicinal chemistry (Shariqah (United Arab Emirates)) 2019.

[18] Chen J, Wang J, Wang M, et al. Retrospect and Risk Analysis of Foot-and-Mouth Disease in China Based on Integrated Surveillance and Spatial Analysis Tools. Frontiers in veterinary science 2019; 6: 511-511.

[19] Zhang W, Zhao Y, Xu Q, Chen Q. Development of a Triplex Real-Time PCR Assay for Simultaneous Detection of Allergenic Ingredients in Processed Food. Czech Journal Of Food Sciences 2018; 36(1): 22-27.

[20] Zhang T, Shi Y, Zhao Y, et al. Boiling and roasting treatment affecting the peanut allergenicity. Annals Of Translational Medicine 2018; 6(18).

[21] Yuan D, Kong J, Li X, Fang X, Chen Q. Colorimetric LAMP microfluidic chip for detecting three allergens: peanut, sesame and soybean. Scientific Reports 2018; 8.

[22] Wang J, Zhang T, Lu Y, et al. Vesicular stomatitis forecasting based on Google Trends. Plos One 2018; 13(1).

[23]Wang F, Huang C, Cao J, et al. A novel and highly efficient AAV6 mutant. Virus Genes 2018; 54(2): 165-171.

[24]Sha Y, Zhang Y, Cao J, et al. Loureirin B promotes insulin secretion through inhibition of K-ATP channel and influx of intracellular calcium. Journal Of Cellular Biochemistry 2018; 119(2): 2012-2021.

[25]Lin W, Niu B, Yi J, et al. Toxicity and Metal Corrosion of Glutaraldehyde-Didecyldimethylammonium Bromide as a Disinfectant Agent. Biomed Research International 2018.

[26]Ding Y, Li Y, Chen Q, Niu B. Advances in Antidiabetic Drugs Targeting Insulin Secretion. Current Pharmaceutical Design 2018; 24(34): 3990-3997.

[27]Chen Y, Wen L, Hu X, Xu R, Chen Q. Discrete Optical Field Manipulation by Ag-Al Bilayer Gratings for Broadband Absorption Enhancement in Thin-Film Solar Cells. Plasmonics 2018; 13(5): 1603-1613.

[28]Zhang Y, Sha Y, Qian K, Chen X, Chen Q. Comparison of three methods for analyzing loureirin B and human serum albumin interaction using capillary electrophoresis. Electrophoresis 2017; 38(7): 1038-1043.

[29]Zhan L, Chen Q, Gu S, Deng X. Determination of milk allergen caseins in foods by ultra performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry. Chinese Journal Of Chromatography 2017; 35(4): 405-412.

[30]Xie Y, Zhao Y, Tan H, Chen Q, Huang J. An ubiquitin-like protein SDE2 negatively affects sucrose-induced anthocyanin biosynthesis in Arabidopsis. Science Bulletin 2017; 62(23): 1585-1592.

[31]Sha Y, Shi Y, Niu B, Chen Q. Cochinchinenin C, a potential nonpolypeptide anti-diabetic drug, targets a glucagon-like peptide-1 receptor. Rsc Advances 2017; 7(77): 49015-49023.

[32]Sha Y, Chen X, Niu B, Chen Q. The Interaction Mode of Groove Binding Between Quercetin and Calf Thymus DNA Based on Spectrometry and Simulation. Chemistry & biodiversity 2017; 14(10).

[33]Niu B, Zhao M, Su Q, et al. 2D-SAR and 3D-QSAR analyses for acetylcholinesterase inhibitors. Molecular Diversity 2017; 21(2): 413-426.

[34]Niu B, Huai W, Deng Z, Chen Q. Fungicidal, Corrosive, and Mutational Effects of Polyhexamethylene Biguanide Combined with 1-Bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione. Biomed Research International 2017.

[35]Huang C, Lan W, Wang F, et al. Establishment of a Human Breast Cancer Model by Fusion PCR for In Vivo and In Vitro Fluorescence Imaging of Human Breast Cancer. DNA And Cell Biology 2017; 36(1): 50-57.

[36]Huang C, Lan W, Wang F, et al. AAV-iRFP labelling of human mesenchymal stem cells for near-infrared fluorescence imaging. Bioscience Reports 2017; 37.

[37]Huai W, Deng Z, Lin W, Chen Q. Enhanced killing of Escherichia coli using a combination of polyhexamethylene biguanide hydrochloride and 1-bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione. Fems Microbiology Letters 2017; 364(21).

[38]Zhang W, Zhu Q, Zhang T, Cai Q, Chen Q. Thermal processing effects on peanut allergen Ara h 2 allergenicity in mice and its antigenic epitope structure. Food Chemistry 2016; 212: 657-662.

[39]Xu Y, Chen Q, Hu S. Androgens regulate the expression of Fkbp5 through androgen receptor in mouse epididymis. Chinese Journal of Andrology 2016; 30(8): 7-13.

[40]Wang H, Wen L, Hu X, et al. Nanoscale Printing Technique and its Applications in Nanophotonics. Nano 2016; 11(9).

[41]Huai W, Deng Z, Chen Q. Bactericidal Activity and Physiological Effects of Combined Application of Poly-Hexamethylene Biguanide Hydrochloride and 1-bromo-3-chloro-5, 5-dimethylimidazolidine-2, 4-dione on Staphylococcus aureus. In: Chao Y, Zhang WF, Li X, ed.^eds., Proceedings Of the 2016 International Conference on Biological Engineering And Pharmacy, 2016; pp. 296-300.

[42]Guan X, Cai Q, Zhang W, Chen Q. Development of a real-time quantitative PCR assay using a TaqMan minor groove binder probe for the detection of alpha-lactalbumin in food. Journal Of Dairy Science 2016; 99(3): 1716-1724.

[43]Gao Y, Deng Z, Wang Q, Chen Q. Determination of tetraiodo-L-thyronine in human serum by competitive indirect chemiluminescence immunoassay. Analytical Methods 2016; 8(22): 4504-4508.

[44]Cai Q, Zhang W-j, Zhu Q-q, Chen Q. Influence of heat treatment on the structure and core IgE-binding epitopes of rAra h 2.02. Food Chemistry 2016; 202: 404-408.

[45]Zhang W-J, Cai Q, Guan X, Chen Q. Detection of peanut (Arachis hypogaea) allergen by Real-time PCR method with internal amplification control. Food Chemistry 2015; 174: 547-552.

[46]Yu Y, Chen Q, Wen L, Hu X, Zhang H-F. Spatial optical crosstalk in CMOS image sensors integrated with plasmonic color filters. Optics Express 2015; 23(17): 21994-22003.

[47]Chen X, Qian K, Chen Q. Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin. European Journal Of Medicinal Chemistry 2015; 93: 492-500.