文铁桥，理学博士、教授、博士生导师。先后在复旦大学遗传所、美国University of Georgia细胞与分子生物学系从事博士后研究，是国际人类基因组成员，中国生命系统仿真学会副理事长。获王宽诚育才奖，宝钢优秀教师奖、公司教学名师。

电话：021-66132512

邮箱：wtq@shu.edu.cn

主要研究领域

主要研究方向包括1、神经干细胞分化调控机制及信号传导途径；2、神经退行性疾病（老年痴呆症、帕金森氏症）发病机制及治疗的分子基础；3、大脑神经发育障碍与精神疾病分子机制。主持多项国家、上海科学基金项目研究。

代表性研究成果

首次发现dcf1基因对维持神经干细胞干性的功能，揭示dcf1基因在大脑皮层发育、神经回路建成的重要作用。主讲基因工程原理被评为上海市精品课程，获上海市教学成果二等奖、公司教学成果一等奖。

近五年代表性论文

1.   Jiao Wang, Weihao Li, Fangfang Zhou, Ruili Feng, Fushuai Wang, Shibo Zhang, Jie Li, Qian Li, Yajiang Wang, Jiang Xie, Tieqiao Wen*, ATP11B deficiency leads to impairment of hippocampal synaptic plasticity, Journal of Molecular Cell Biology, 2019.6.1, 11: 688~702

2.   Guanghong Luo, Ruili Feng, Yangyang Sun, Lili Zheng, Yajiang Wang, Yanlu Chen, Tieqiao Wen*, Dendritic cell factor 1 inhibits proliferation and migration and induces apoptosis of neuroblastoma cells by inhibiting the ERK signaling pathway, Oncology Reports, 2019.41.1:103-112

3.   Qiang Liu, Ruili Feng, Yu Chen, Guanghong Luo, Huang Yan, Ling Chen, Rongfei Lin, Yuqiang Ding, Tieqiao Wen*, Dcf1 Triggers Dendritic Spine Formation and Facilitates Memory Acquisition, Mol Neurobiol., 2018.1, 147(54)

4.   Guanghong Luo, Yangyang Sun, Ruili Feng, Qinping Zhao, Tieqiao Wen*, ARL3 subcellular localization and its suspected role in autophagy, Biochimie, 2018.154:187-193

5.   Jiao Wang , Jie Li, Qian Wang, Fangfang Zhou, Qian Li, Weihao Li, Yangyang Sun, Yanli Wang, Yihui Guan, Minghong Wu, Tieqiao Wen*, Dcf1 Deficiency Attenuates the Role of Activated Microglia During Neuroinflammation, Frontiers in Molecular Neuroscience, 2018.07.30, 11: 0~256

6.   Jiao Wang, Fangfang Zhou, Dong Wang, Jie Li, Dongfang Lu, Qian Li, Hong Zhou, Weihao Li, Qian Wang, Yiliu Wu, Jiang Xie, Tieqiao Wen*, Interaction of DCF1 with ATP1B1 induces impairment in astrocyte structural plasticity via the P38 signaling pathway, Experimental Neurology, 2018.1.12, 302: 214~229

7.   Qiang Liu , Linhua Gan , Jian Ni , Yu Chen, Yanlu Chen, Zhili Huang, Xu Huang, Tieqiao Wen*, Dcf1 Improves Behavior Deficit in Drosophila and Mice Caused by Optogenetic Suppression , J Cell Biochem, 2017.4.12, 118(42): 4210~4215

8.   Shiqing Zhang, Ruili Feng, Yanhui Li, Linhua Gan, Fangfang Zhou, Shiquan Meng, Qian Li, Tieqiao Wen*Degradation of alpha-synuclein by dendritic cell factor 1 delays neurodegeneration and extends lifespan in Drosophila , Neurobiol Aging. 2018. 67: 67-74

9.   Jieyun Shi, Qian Li, Tieqiao Wen* Dendritic Cell Factor 1-Knockout Results in Visual Deficit Through the GABA System in Mouse Primary Visual Cortex , Neurosci Bull. 2018. 34(3):465-475

10.  Jiao Wang, Qian Li, Yanyan Kong, Fangfang Zhou, Jie Li, Weihao Li, Kai Wang, Wu, Ting, Yihui Guan, Jiang Xie, Tieqiao Wen*Biosystems Study of the Molecular Networks Underlying Hippocampal Aging Progression and Anti-aging Treatment in Mice  Front Aging Neurosci. 2017.6;9:393.

近五年获发明专利授权

1.   文铁桥，王董，王娇，冯瑞丽，dcf1基因调控ATP1B1的表达的应用，2017.12.22，中国， ZL201610371968.4

2.   文铁桥，谢雨琼，杨眉，杨清波，基因在脑胶质瘤细胞的抑制与凋亡中的应用，2012.10.11，中国，ZL201210382456.X